Note that I believe the version below specifies the version of the response file 'standard' being used (ignore it): InstallShield Silent Version=v7.00 File=Response File. I have noticed that InstallShield doesn't always support all command line switches correctly, so if for example '/uninstall' doesn't work try '-uninstall'. I ran the below silent installation commands (setup.exe /A /Z /S 'Setup.iss') (setup.exe -s 'Setup.iss'). InstallShield Silent Version=v7.00.